Fibrosis is the result of chronic inflammatory reactions induced by a variety of persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury.
Inflammation-related fibrosis is characterized by the excessive deposition of extracellular matrix components, particularly collagen, stemming from persistent inflammation within tissues or organs. This progression often culminates in the development of fibrous or scar tissue, compromising the normal functionality of the affected organ.
Allinky is generating efficacy data on NASH and IPF.
NASH (Non-Alcoholic Steatohepatitis): NASH is a liver condition characterized by the accumulation of fat in the liver, along with inflammation and liver damage. Unlike simple fatty liver (accumulation of fat in the liver without inflammation), NASH involves inflammation and can progress to cirrhosis, a serious condition that affects liver function. NASH is not related to alcohol consumption and is a serious medical condition
Figure. Optical microscopy image of mouse liver tissue after 16 weeks of CDAA diet resulting in NASH. Four weeks of treatment with Alosertib (20 mg/kg) results in markedly reduced fat deposits.
Figure: Histology images of mouse lung tissue from a model of Bleomycin-induced Idiopathic Pulmonary Fibrosis. Oral treatment with Alosertib (40 mg/kg) significantly reduces fibrosis in a manner comparable to the reference drug Pirfenidone (100 mg/kg).
IPF (Idiopathic Pulmonary Fibrosis): IPF is a chronic and progressive lung disease characterized by the formation of scar tissue (fibrosis) in the lungs. It is called “idiopathic” because the exact cause of the disease is unknown in most cases. IPF makes breathing difficult as the lungs become less elastic and less able to function properly.
Figure: Histology images of mouse lung tissue from a model of Bleomycin-induced Idiopathic Pulmonary Fibrosis. Oral treatment with Alosertib (40 mg/kg) significantly reduces fibrosis in a manner comparable to the reference drug Pirfenidone (100 mg/kg).
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