Autoinflammatory diseases encompass a range of disorders characterized by dysregulation of the innate immune system, leading to episodes of systemic inflammation without the typical involvement of autoantibodies or antigen-specific T cells. Unlike autoimmune diseases, where the immune system mistakenly attacks the body’s own cells and tissues, autoinflammatory diseases primarily involve the innate immune system’s overactivation, resulting in heightened inflammation.
These conditions often present with recurrent episodes of fever, rash, joint pain, and inflammation affecting various organs, such as the skin, joints, and internal organs. Some well-known examples of autoinflammatory diseases include familial mediterranean fever (FMF), TNF receptor-associated periodic syndrome (TRAPS), and cryopyrin-associated periodic syndromes (CAPS), among others.
Allinky is generating efficacy data on autoinflammatory diseases as well as immune-mediated and non-immune mediated inflammatory diseases.
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