Publications - Allinky Biopharma

The following articles authored by Allinky's team and founders are helpful to understand the scientific background behind Allinky's approach for discovery and development of new therapeutics:

• Reduced brain insulin-like growth factor I function during aging. Mol Cell Neurosci (January 2012)
  

• The many faces of insulin-like signalling in the brain. Nat Rev Neurosci (March 2012)

• Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology. Mol Psychiatry (October 2011)
  

• Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis (August 2011)
  

• T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity (August 2011)
  

• Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS. Neuron 834-46 (September 2010)
  

• Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nat Immunol. 2009 Aug;10(8):880-8. (June 2009)
• Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling. Mol Biol Cell. 2014-25 (May 2008)
• Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes. Life Sci. 1452-60 (October 2007)
• Interfering with MAP kinase docking interactions: implications and perspective for the p38 route. Cell Cycle 528-33 (March 2007)
• Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490. Glia 1313-24 (October 2007)